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KMID : 0928520010110040500
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Korean Journal of Lipidology
2001 Volume.11 No. 4 p.500 ~ p.514
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The Prevalence of Dyslipidemia by New Guidelines NCEP-ATP III in Type 2 Diabetes
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Park Mi-Kyoung
Kang Do-Young
Kim Duk-Kyu
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Abstract
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Objective: Recently, the NCEP-ATP III report updates the new guidelines for intensive cholesterol-lowering therapy and the new guidelines are expected to substantially increase the number of patients being treated for high cholesterol. The aim of this study is to evaluate the prevalence of dyslipidemia by the new guidelines ATP-III comparing with that of ATP-II and to analyze lipid profiles and metabolic syndrome in type 2 diabetic patients.
Methods: The data were collected from review of the medical records retrospectively on 435 type 2 diabetic patients [M:216, F: 219] who were admitted in Dong-A University Hospital during last 5 years (1996. 7. 1∼2001. 6. 30). The criteria of dylipidemia included any one of LDL-C ≥130 (100 in CAD) mg/dL, HDL-C <35 (45 in women) mg/dL, or TG ≥200 (150 in CAD) mg/dL by ATP-II and any one of LDL-C ≥100 mg/dL, HDL-C <40 (50 in women) mg/dL, or TG ≥150 mg/dL by ATP-III. The percentages with none, one, two, and three values outside of the target lipid levels and high-, borderline-, low-risk lipid values were analyzed.
Results: The prevalences of dyslipidemia was 71% by ATP-II and 89% by ATP-III (25% increment, p<0.0001). Obese group showed significantly higher prevalence than nonobese group in ATP-II (81, 70%, respectively, p=0.025) but not in ATP-III (93, 88%, respectively, p=0.155). The most common pattern of dyslipidemia was increased LDL-C only in both ATP-II and III. The mean concentrations of total cholesterol and LDL-C in women were significantly higher than in men. In total cholesterol and HDL-C levels, the percentage of high risk group in women was higher than in men. The percentage of two or three out of target lipid values was higher by ATP-III (67%) than ATP-II (49%) and most of hospitalized type 2 diabetic patients were outside of target lipid values (91% by ATP-II and 95% by ATP-III). The prevalence of metabolic syndrome was 56% and it was significantly higher in women than in men.
Conclusions: About 18% of diabetic patients were newly included in dyslipidemic group by new guideline ATP-III. The proportion of patients with metabolic syndrome was 56%. Because women showed greater proportion with high risk of total cholesterol, HDL-C, and metabolic syndrome, we need to manage more aggressively in this group.
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KEYWORD
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NCEP-ATP III, Dyslipidemia, Diabetes mellitus, Prevalence
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